Lu Zhuo-Zhuang, Wang Li-Sheng, Wu Chu-Tse
Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850.
Sheng Li Ke Xue Jin Zhan. 2004 Apr;35(2):135-8.
Notch signaling plays a vital role in cell fate decisions in both invertebrate and vertebrate development. Signals exchanged between neighboring cells through the Notch receptor amplify and consolidate molecular differences, which eventually dictate cell fates. In this review, the details of notch signaling will be discussed, with a focus on Lin/Notch repeats (CSL) independent modes.
Notch信号通路在无脊椎动物和脊椎动物发育过程中的细胞命运决定中起着至关重要的作用。相邻细胞通过Notch受体交换的信号放大并巩固分子差异,最终决定细胞命运。在这篇综述中,将讨论Notch信号通路的细节,重点是独立于Lin/Notch重复序列(CSL)的模式。