Berni Canani R, Rapacciuolo L, Romano M T, Tanturri de Horatio L, Terrin G, Manguso F, Cirillo P, Paparo F, Troncone R
Department of Pediatrics, University Federico II of Naples, Via S. Pansini, 5, 80131 Naples, Italy.
Dig Liver Dis. 2004 Jul;36(7):467-70. doi: 10.1016/j.dld.2004.02.009.
Faecal calprotectin (FC) is a new marker of intestinal inflammation. Data on FC in paediatric gastroenterology clinical practice are still scarce.
To assess FC values in different paediatric gastrointestinal diseases comparing them with those obtained in healthy children.
Two hundred and eighty-one children (age range 13-216 months) consecutively referred for gastrointestinal symptoms. Seventy-six healthy controls (age range 13-209 months). The exclusion criteria in healthy children were the following: any known underlying chronic disease or a history of abdominal pain, diarrhoea, acute respiratory tract infection, intake of non-steroidal anti-inflammatory drugs, gastric acidity inhibitors, antibiotics, drugs influencing gut motility, and menstrual or nasal bleeding in the last 3 weeks.
Stool samples stored, prepared and analyzed by an ELISA assay.
In healthy children the median FC value was 28.0 microg/g (15-57 interquartile range) with a 95th percentile value of 95.3 microg/g. An increase in FC concentration was observed in all diseases characterized by gastrointestinal mucosa inflammation, and the active inflammatory bowel disease patients showed the higher FC values. All children affected by functional bowel disorders or by non-inflammatory diseases showed normal values. We calculated an optimized FC cut off value of 102.9266 microg/g (revealed by the receiver operating characteristic curve) to distinguish patients with active organic/inflammatory disorders from healthy subjects and from patients with functional bowel disorders.
Calprotectin is a sensitive, but not disease specific, marker to easily detect inflammation throughout the whole gastrointestinal tract. It may help in identifying an organic disease characterized by intestinal mucosa inflammation and in the differential diagnosis of functional bowel disorders.
粪便钙卫蛋白（FC）是肠道炎症的一种新标志物。儿科胃肠病临床实践中关于FC的数据仍然很少。
评估不同儿科胃肠道疾病中的FC值，并与健康儿童的FC值进行比较。
连续转诊的281名有胃肠道症状的儿童（年龄范围13 - 216个月）。76名健康对照者（年龄范围13 - 209个月）。健康儿童的排除标准如下：任何已知的潜在慢性疾病或腹痛、腹泻、急性呼吸道感染病史，在过去3周内摄入非甾体抗炎药、胃酸抑制剂、抗生素、影响肠道蠕动的药物，以及月经或鼻出血。
粪便样本通过酶联免疫吸附测定法进行储存、制备和分析。
健康儿童的FC中位数为28.0微克/克（四分位间距15 - 57），第95百分位数为95.3微克/克。在所有以胃肠道黏膜炎症为特征的疾病中均观察到FC浓度升高，且活动性炎症性肠病患者的FC值最高。所有患有功能性肠病或非炎症性疾病的儿童FC值均正常。我们计算出一个优化的FC临界值为102.9266微克/克（由受试者工作特征曲线得出），以区分患有活动性器质性/炎症性疾病的患者与健康受试者以及功能性肠病患者。
钙卫蛋白是一种敏感但非疾病特异性的标志物，可轻松检测整个胃肠道的炎症。它可能有助于识别以肠道黏膜炎症为特征的器质性疾病，并用于功能性肠病的鉴别诊断。
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