左乙拉西坦治疗慢波睡眠期药物难治性持续性棘慢波的疗效。
Efficacy of levetiracetam in pharmacoresistant continuous spikes and waves during slow sleep.
作者信息
Capovilla G, Beccaria F, Cagdas S, Montagnini A, Segala R, Paganelli D
机构信息
Department of Child Neuropsychiatry, C. Poma Hospital, Mantova, Italy.
出版信息
Acta Neurol Scand. 2004 Sep;110(3):144-7. doi: 10.1111/j.1600-0404.2004.00289.x.
OBJECTIVE
To evaluate the efficacy of levetiracetam (LEV) in continuous spikes and waves during slow sleep (CSWS). Despite first description dates back to 1971, no agreement exists about CSWS treatment. The condition is rare and controlled clinical trials are very difficult to perform, so the reports about efficacy of different drugs are anecdotal.
PATIENTS AND METHODS
We introduced LEV in three children affected by symptomatic focal epilepsy and pharmacoresistant CSWS and evaluated clinical, neuropsychological and electroencephalographic outcome.
RESULTS
Two cases responded completely, one case showed only a mild reduction of spikes and waves during slow sleep.
CONCLUSION
Even if our report is anecdotal, LEV expands the spectrum of antiepileptic drugs that can be used for the treatment of CSWS. LEV efficacy should be confirmed in larger series.
目的
评估左乙拉西坦（LEV）治疗慢波睡眠期持续棘慢波（CSWS）的疗效。尽管CSWS最早于1971年被描述，但对于其治疗尚无共识。该病症较为罕见，很难开展对照临床试验，因此关于不同药物疗效的报道多为个案。
患者与方法
我们对3例患有症状性局灶性癫痫且药物难治性CSWS的儿童使用了左乙拉西坦，并评估了临床、神经心理学和脑电图结果。
结果
2例完全缓解，1例仅显示慢波睡眠期棘慢波轻度减少。
结论
即便我们的报道为个案，但左乙拉西坦拓宽了可用于治疗CSWS的抗癫痫药物谱。左乙拉西坦的疗效应在更大规模的研究中得到证实。
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