Vogelstein Bert, Kinzler Kenneth W
Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA.
Nat Med. 2004 Aug;10(8):789-99. doi: 10.1038/nm1087.
The revolution in cancer research can be summed up in a single sentence: cancer is, in essence, a genetic disease. In the last decade, many important genes responsible for the genesis of various cancers have been discovered, their mutations precisely identified, and the pathways through which they act characterized. The purposes of this review are to highlight examples of progress in these areas, indicate where knowledge is scarce and point out fertile grounds for future investigation.
本质上，癌症是一种基因疾病。在过去十年中，许多导致各类癌症发生的重要基因已被发现，其突变被精确识别，且它们发挥作用的途径也已明确。本综述的目的是突出这些领域的进展实例，指出知识匮乏之处，并指明未来研究的沃土。
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