手术切缘和Gleason评分作为伴或不伴8号染色体短臂等位基因失衡的前列腺癌术后复发的预测指标。
Surgical margin and Gleason score as predictors of postoperative recurrence in prostate cancer with or without chromosome 8p allelic imbalance.
作者信息
Zhou Wei, Goodman Michael, Lyles Robert H, Lim So Dug, Williams Tanisha Y, Rusthoven Kyle E, Mandel Jack S, Amin Mahul B, Petros John A
机构信息
Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, 1365 Clifton Road NE, Atlanta, GA 30322, USA.
出版信息
Prostate. 2004 Sep 15;61(1):81-91. doi: 10.1002/pros.20086.
BACKGROUND
Identification of prostate cancer patients at risk for postoperative disease recurrence is an important clinical issue. Existing pathological markers can predict disease recurrence only to a certain extent, and there is a need for more accurate predictors.
METHODS
Using "counting alleles," a novel experimental method, we determined allelic status of chromosome 8p in 107 prostatectomy specimens. Statistical analyses examined the association between pathologic predictors (Gleason score, stage, surgical margin, etc.) and cancer recurrence in patients with and without 8p allelic imbalance (8p AI).
RESULTS
8p AI cancers were more likely to recur in the presence of a positive surgical margin, whereas recurrence of 8p retaining tumors was associated with the Gleason score, but not with the surgical margin.
CONCLUSIONS
Our findings suggest that chromosome 8p allelic status affects the predictive value of "traditional" markers of prostate cancer recurrence. If confirmed by larger studies, these results may have important clinical implications.
背景
识别有术后疾病复发风险的前列腺癌患者是一个重要的临床问题。现有的病理标志物仅能在一定程度上预测疾病复发，因此需要更准确的预测指标。
方法
我们使用一种新的实验方法“等位基因计数”，确定了107例前列腺切除标本中8号染色体短臂（8p）的等位基因状态。统计分析检查了有或无8p等位基因失衡（8p AI）患者的病理预测指标（ Gleason评分、分期、手术切缘等）与癌症复发之间的关联。
结果
手术切缘阳性时，8p AI的癌症更易复发，而保留8p的肿瘤复发与Gleason评分相关，与手术切缘无关。
结论
我们的研究结果表明，8号染色体短臂等位基因状态会影响前列腺癌复发“传统”标志物的预测价值。如果更大规模的研究证实这些结果，可能具有重要的临床意义。
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