Hai Li, Wu Lin-yan, Huang Juan, Cheng Li, Wu Yong
Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610061, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2004 Jul;35(4):552-4.
To synthesize N1-(aryl)alkyloxyacyl-5-fluorouracil derivatives and investigate their antitumor activities.
Title compounds (I) were prepared by 5-fluorouracil which was trimethylsilylated by hexamethyl-di-silazane, and then acylated. Hydrogenization of compounds (I) brought on compounds (II), which were esterified to produce title compounds (III) afterwards.
Twelve title compounds were synthesized.
These compounds were designed products confirmed by 1H-NMR, IR and MS spectral data.
合成N1-(芳基)烷氧基酰基-5-氟尿嘧啶衍生物并研究其抗肿瘤活性。
通过用六甲基二硅氮烷对5-氟尿嘧啶进行三甲基硅烷基化，然后进行酰化反应制备标题化合物（I）。化合物（I）的氢化反应得到化合物（II），随后将其酯化以制备标题化合物（III）。
合成了12种标题化合物。
这些化合物是经1H-NMR、IR和MS光谱数据确证的设计产物。
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