Ledvina M, Bartos F, Wimmerová J, Kosar A, Hodánová M
Physiol Bohemoslov. 1978;27(6):521-9.
The amount of insoluble elastin and its content of desmosine cross-links were investigated in aortas of chick embryos, to which D-penicillamine was administered on the 6th or 14th--16th day of incubation. D-Penicillamine was shown to alter the formation and maturation of elastin. Using lower doses (less than 50 mg) the weight of pooled aortic elastin is higher as compared with controls (related to 1 mg of elastin or to total weight of elastin). Increased isodesmosine:desmosine ratio in these samples indicates that this elastin is very young. On the other hand, a high dose of D-penicillamine (100 mg) decreased the content of elastin and also of its desmosine cross-links. The authors explain their findings by counteraction of two factors due to administration of penicillamine: the increased solubility of "insoluble elastin", and the decreased cross-link formation.
研究了在孵化第6天或第14 - 16天给予D - 青霉胺的鸡胚主动脉中不溶性弹性蛋白的含量及其锁链素交联物的含量。结果表明，D - 青霉胺会改变弹性蛋白的形成和成熟过程。使用较低剂量（小于50毫克）时，与对照组相比，汇集的主动脉弹性蛋白重量更高（相对于1毫克弹性蛋白或弹性蛋白总重量）。这些样本中异锁链素：锁链素比例的增加表明这种弹性蛋白非常年轻。另一方面，高剂量的D - 青霉胺（100毫克）会降低弹性蛋白及其锁链素交联物的含量。作者通过青霉胺给药导致的两个因素的相互作用来解释他们的发现：“不溶性弹性蛋白”溶解度的增加和交联形成的减少。
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