[淋巴靶向剂型的制备：平阳霉素吸附于活性炭纳米粒]
[Preparation of lymphatic targeting dosage form: pingyangmycin absorbed on activated carbon nanoparticles].
作者信息
Sun Ming-lei, Wen Yu-ming, Wang Chang-mei, Li Long-jiang, Wang Xiao-yi
机构信息
Dept. of Stomatology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
出版信息
Hua Xi Kou Qiang Yi Xue Za Zhi. 2004 Jun;22(3):183-5.
OBJECTIVE
To prepare anticancer nanoparticles for targeting therapy for oral cancer lymph node metastasis.
METHODS
The activated carbon nanoparticles (CH-NP) were prepared for drug carrier. Pingyangmycin (PYM), a high sensitive anticancer drug for oral squamous cell carcinoma, were selected as model drug. The activated carbon nanoparticles and PYM were mixed with saline and shaken 20 minutes so that PYM was absorbed on activated carbon enough, resulting in a new formulation of PYM (PYM-CH-NP). The absorbency of PYM on activated carbon nanoparticles was evaluated.
RESULTS
The diameter distribution for CH-NP ranged form 136 nm, to 540 nm, the average diameter was 176 nm. The proportion of CH-NP to PYM was increased and more absorbency of PYM on activated carbon nanoparticles was achieved.
CONCLUSION
The activated carbon nanoparticles has high absorbency of PYM. The new formulation PYM-CH-NP can be used as targeting therapy of cervical lymph node metastasis by peri-cancer submucosal injection.
目的
制备用于口腔癌淋巴结转移靶向治疗的抗癌纳米粒子。
方法
制备活性炭纳米粒子（CH-NP）作为药物载体。选择对口腔鳞状细胞癌高度敏感的抗癌药物平阳霉素（PYM）作为模型药物。将活性炭纳米粒子与PYM与生理盐水混合并振荡20分钟，使PYM充分吸附在活性炭上，得到新的PYM制剂（PYM-CH-NP）。评估PYM在活性炭纳米粒子上的吸附率。
结果
CH-NP的直径分布范围为136nm至540nm，平均直径为176nm。CH-NP与PYM的比例增加，PYM在活性炭纳米粒子上的吸附率更高。
结论
活性炭纳米粒子对PYM具有高吸附率。新制剂PYM-CH-NP可通过癌周黏膜下注射用于颈部淋巴结转移的靶向治疗。
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