上皮-间质转化：发育与转移中的 Twist 蛋白

Epithelial-mesenchymal transitions: twist in development and metastasis.

作者信息

Kang Yibin, Massagué Joan

机构信息

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

出版信息

Cell. 2004 Aug 6;118(3):277-9. doi: 10.1016/j.cell.2004.07.011.

DOI:10.1016/j.cell.2004.07.011

PMID:15294153

Abstract

Epithelial-mesenchymal transitions (EMT) are vital for morphogenesis during embryonic development and are also implicated in the conversion of early stage tumors into invasive malignancies. Several key inducers of EMT are transcription factors that repress E-cadherin expression. A recent report in Cell (Yang et al., 2004) adds Twist to this list and links EMT to the ability of breast cancer cells to enter the circulation and seed metastases.

摘要

上皮-间质转化（EMT）在胚胎发育过程中的形态发生中至关重要，并且也与早期肿瘤转变为侵袭性恶性肿瘤有关。EMT的几个关键诱导因子是抑制E-钙黏蛋白表达的转录因子。《细胞》杂志最近的一篇报道（Yang等人，2004年）将Twist列入此清单，并将EMT与乳腺癌细胞进入循环系统并形成转移灶的能力联系起来。