Monassier J P, Gressin V, Louvard Y, Hanssen M, Levy J, Katz O
Service de cardiologie, centre hospitalier du Hasenrain, Mulhouse.
Arch Mal Coeur Vaiss. 1992 May;85(5 Suppl):743-50.
Myocardial reperfusion is associated with a number of clinical, electrocardiographic (arrhythmias, conduction defects, ST segment changes), haemodynamic and biological events. The commonest arrhythmias are ventricular extra-systoles, rapid ventricular tachycardias, and accelerated idio-ventricular rhythms. Reperfusion bradycardias are less common. When the arrhythmia is related to ischaemia it usually regresses when perfusion is restored. Reperfusion of the inferior wall of the left ventricle is often associated with sinus bradycardia and hypotension. The ST segment changes may evolve in two different ways: progressive regression or accentuation of ST elevation. When the responsible artery is recanalized, there is an immediate rise in plasma enzyme and myoglobin concentrations. The peak CPK concentration is usually observed after the 12th hours. The diagnostic value of the reperfusion syndrome lies in the interpretation of rapid ventricular tachycardias, accelerated idio-ventricular rhythms, ST segment changes and immediate rise in plasma CPK levels. The clinical risks of the reperfusion syndrome are low, practically never rhythmic and only exceptionally haemodynamic.
心肌再灌注与许多临床、心电图(心律失常、传导缺陷、ST段改变)、血流动力学及生物学事件相关。最常见的心律失常为室性早搏、快速室性心动过速及加速性室性自主心律。再灌注性心动过缓较少见。当心律失常与缺血相关时,灌注恢复后通常会消退。左心室下壁再灌注常伴有窦性心动过缓和低血压。ST段改变可能以两种不同方式演变:ST段抬高逐渐消退或加重。当相关动脉再通时,血浆酶和肌红蛋白浓度会立即升高。CPK浓度峰值通常在12小时后出现。再灌注综合征的诊断价值在于对快速室性心动过速、加速性室性自主心律、ST段改变及血浆CPK水平立即升高的解读。再灌注综合征的临床风险较低,实际上几乎不会引起节律异常,仅在极少数情况下会影响血流动力学。