免疫学基础：抗原加工相关转运体（TAP）的结构与功能

The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.

作者信息

Abele Rupert, Tampé Robert

机构信息

Institute of Biochemistry, Biozentrum Frankfurt, Johann Wolfgang Goethe-University, D-60439 Frankfurt am Main, Germany.

出版信息

Physiology (Bethesda). 2004 Aug;19:216-24. doi: 10.1152/physiol.00002.2004.

DOI:10.1152/physiol.00002.2004

PMID:15304636

Abstract

The transporter associated with antigen processing (TAP) is essential for peptide delivery from the cytosol into the lumen of the endoplasmic reticulum (ER), where these peptides are loaded on major histocompatibility complex (MHC) I molecules. Loaded MHC I leave the ER and display their antigenic cargo on the cell surface to cytotoxic T cells. Subsequently, virus-infected or malignantly transformed cells can be eliminated. Here we discuss the structure, function, and mechanism of TAP as a central part of the peptide-loading complex. Furthermore, aspects of virus and tumor escape strategies are presented.

摘要

抗原加工相关转运体（TAP）对于将肽从细胞质转运至内质网（ER）腔至关重要，这些肽在内质网腔中加载到主要组织相容性复合体（MHC）I类分子上。加载了肽的MHC I离开内质网，并将其抗原性货物展示在细胞表面以供细胞毒性T细胞识别。随后，病毒感染或恶性转化的细胞可被清除。在此，我们讨论TAP作为肽加载复合体核心部分的结构、功能及机制。此外，还介绍了病毒和肿瘤逃逸策略的相关方面。