Gaglia Jason L, Wyckoff Jennifer, Abrahamson Martin J
Joslin Diabetes Center, Beth Israel Deaconess Medical Center, 1 Joslin Place, Boston, MA 02215, USA.
Med Clin North Am. 2004 Jul;88(4):1063-84, xii. doi: 10.1016/j.mcna.2004.04.010.
The geriatric population is at particular risk for developing hyperglycemic crises with the development of diabetes. With increasing age, insulin secretory reserve, insulin sensitivity, and thirst mechanisms decrease. The elderly are particularly vulnerable to hyperglycemia and dehydration, the key components of hyperglycemic emergencies. If recognized early, hyperglycemia can frequently be treated in the outpatient setting even with moderate or large ketonuria, provided patients can take fluids, monitor blood glucose frequently, and follow standard "sick day rules." With increased diabetes surveillance and aggressive early treatment of hyperglycemia and its complications, morbidity and mortality from acute diabetic crises in the geriatric population can be greatly reduced.
老年人群在患糖尿病时发生高血糖危象的风险尤为突出。随着年龄增长,胰岛素分泌储备、胰岛素敏感性和口渴机制都会下降。老年人特别容易出现高血糖和脱水,而这正是高血糖急症的关键组成部分。如果能早期识别,即使存在中度或大量酮尿,高血糖在门诊环境中通常也可得到治疗,前提是患者能够摄入液体、频繁监测血糖并遵循标准的“患病日规则”。随着糖尿病监测的加强以及对高血糖及其并发症的积极早期治疗,老年人群急性糖尿病危象的发病率和死亡率可大幅降低。