[蛋白S水平降低患者的门静脉血栓形成]
[Portal vein thrombosis in a patient with lowered protein S level].
作者信息
Fechner L, Lotterer E, Fleig W E
机构信息
Klinik und Poliklinik für Innere Medizin I, Martin-Luther-Universität Halle-Wittenberg, Halle/Saale.
出版信息
Dtsch Med Wochenschr. 2004 Aug 20;129(34-35):1798-801. doi: 10.1055/s-2004-829031.
HISTORY AND CLINICAL FINDINGS
In a 39-year-old man with increasing spasmodic epigastric pain, nausea and vomiting, varices of the esophagus and the gastric fundus were found endoscopically.
INVESTIGATIONS
A portal vein thrombosis and a consecutive thrombosis of the splenic vein were diagnosed by colour Doppler sonography and angio CT. A protein S deficiency (59 %) was found to be the underlying illness.
TREATMENT AND COURSE
The thrombosis and the resulting clinical symptoms completely resolved shortly after starting therapeutic heparinization. For six months, the patient has been without complaints or clinical symptoms.
CONCLUSION
Hence, an isolated protein S deficiency can be the cause for a portal vein thrombosis.
病史与临床发现
一名39岁男性，上腹部痉挛性疼痛加剧，伴有恶心和呕吐，内镜检查发现食管和胃底静脉曲张。
检查
彩色多普勒超声和血管CT诊断为门静脉血栓形成及随后的脾静脉血栓形成。发现潜在病因是蛋白S缺乏（59%）。
治疗与病程
开始治疗性肝素化后不久，血栓形成及由此产生的临床症状完全缓解。六个月来，患者无不适或临床症状。
结论
因此，单纯的蛋白S缺乏可能是门静脉血栓形成的原因。
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