Giovannangeli M, Lanza M, Lanza J P
C R Seances Soc Biol Fil. 1978;172(3):505-11.
The authors made conspicuous in the rat the appearance of "diabetes insipidus" induced by two lithium salts: chloride and carbonate administered orally, with increasing doses in food. The polyuria, polydipsia and urinary hypotony are reversible and disappeared with stopping the treatment. The animals became insensible to the exogenous antidiuretic hormon during the treatment and progressively became sensible again during the following twenty days so suggesting a nephrogenic mechanism by lithium: either a loss of ADH activity, either the abolition of intrarenal osmotic pressure gradient.
作者通过在大鼠食物中口服递增剂量的两种锂盐（氯化物和碳酸盐），成功诱发了“尿崩症”。多尿、多饮和尿比重降低是可逆的，停止治疗后症状消失。在治疗期间，动物对外源性抗利尿激素不敏感，在随后的二十天里逐渐恢复敏感，这表明锂导致了一种肾性机制：要么是抗利尿激素活性丧失，要么是肾内渗透压梯度消失。
