Nel Mirinda, Lobetti Remo G, Keller Ninette, Thompson Peter N
Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, South Africa.
J Vet Intern Med. 2004 Jul-Aug;18(4):471-6. doi: 10.1892/0891-6640(2004)18<471:pvoblb>2.0.co;2.
Canine babesiosis typically causes hemolytic anemia but also can result in multiple organ dysfunction. Human patients with severe disease often have persistent hyperlactatemia, and blood lactate concentration is correlated with survival rate. In dogs, blood lactate concentration has been shown to be of prognostic value in patients with gastric dilatation-volvulus and in dogs admitted to intensive care units. Serial blood lactate and glucose concentrations and hematocrit on admission were determined in 90 dogs with naturally occurring, severe or complicated canine babesiosis. Forty-five dogs (50%) had hyperlactatemia (blood lactate concentration >22.5 mg/dL) and 20 (22.2%) had hypoglycemia (blood glucose concentration <59.4 mg/dL) at presentation. Measurements significantly associated with mortality were hypoglycemia on admission, blood lactate concentration >45 mg/dL on admission, blood lactate concentration >22.5 mg/dL at 8, 16, and 24 hours after admission, and increase or <50% decrease in blood lactate concentration within 8 and 16 hours after admission. Blood lactate concentration persistently >40 mg/dL indicated a very poor prognosis. We conclude that serial blood lactate measurements are useful in predicting survival in dogs with severe and complicated canine babesiosis.
犬巴贝斯虫病通常会引发溶血性贫血，但也可能导致多器官功能障碍。患有严重疾病的人类患者常出现持续性高乳酸血症，且血乳酸浓度与生存率相关。在犬类中，血乳酸浓度已被证明对患有胃扩张 - 扭转的犬以及入住重症监护病房的犬具有预后价值。对90只自然感染严重或复杂犬巴贝斯虫病的犬测定了入院时的系列血乳酸、血糖浓度及血细胞比容。45只犬（50%）在就诊时出现高乳酸血症（血乳酸浓度>22.5 mg/dL），20只犬（22.2%）出现低血糖（血糖浓度<59.4 mg/dL）。与死亡率显著相关的测量指标包括入院时低血糖、入院时血乳酸浓度>45 mg/dL、入院后8、16和24小时血乳酸浓度>22.5 mg/dL，以及入院后8至16小时内血乳酸浓度升高或降低<50%。血乳酸浓度持续>40 mg/dL表明预后极差。我们得出结论，系列血乳酸测量对于预测患有严重和复杂犬巴贝斯虫病的犬的生存情况有用。
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