Ma Hong-jing, Xiao Lu-lu, Yin Xiao-lin, Guo Kun-yuan, Ye Xin
Department of Hematology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China.
Di Yi Jun Yi Da Xue Xue Bao. 2004 Aug;24(8):900-3.
To analyze the polymorphism and haplotypes of HLA-Cw and detect HLA-A, B, Cw and DRB1 allele frequencies in Guangdong Han population.
An auto semi-quantitative PCR with reverse sequence-specific oligonucleo- tide was adopted to explore the HLA-A, B, Cw and DRB1 genotypes of 185 bone marrow donors.
Eleven HLA-Cw alleles were obtained in which Cw*03 (0.2580), 07 (0.1887), 01 (0.1732), and 08 (0.1071) had much higher allele frequencies. A total of 7 HLA-Cw-A, 20 HLA-Cw-B and 10 HLA-Cw-DRB1 haplotypes were found.
HLA-Cw alleles have richer polymorphisms and their linkage disequilibrium with HLA-A, B, DRB1 exhibits geographic genetic characteristics.
分析广东汉族人群中HLA-Cw的多态性和单倍型，并检测HLA-A、B、Cw和DRB1等位基因频率。
采用反向序列特异性寡核苷酸的自动半定量聚合酶链反应（PCR）检测185例骨髓供者的HLA-A、B、Cw和DRB1基因型。
共获得11个HLA-Cw等位基因，其中Cw*03（0.2580）、07（0.1887）、01（0.1732）和08（0.1071）的等位基因频率较高。共发现7种HLA-Cw-A单倍型、20种HLA-Cw-B单倍型和10种HLA-Cw-DRB1单倍型。
HLA-Cw等位基因具有更丰富的多态性，其与HLA-A、B、DRB1的连锁不平衡呈现出地理遗传特征。
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