Lin Yuan-quan, Jia Jun, Liu Wen-feng, Zhang Jun
Department of Neurosurgery, Shenzhen Longgang Central Hospital, Shenzhen 518116, China.
Di Yi Jun Yi Da Xue Xue Bao. 2004 Aug;24(8):963-4.
To observe the changes in intracranial pressure (ICP) and brain tissue oxygen tension (PO(2)) and their significance in severe head injury treated by moderate hypothermia (33-35 degrees Celsius).
Eighteen patients with severe head injury were treated with moderate hypothermia group and probes were deployed in the cerebral cortex for measuring their ICP and PO(2) under continuous monitoring. Another 14 similar patients receiving the same treatment but without hypothermia served as the control group.
In moderate hypothermia group the ICP gradually decreased and PO(2) increased after 24 hours of hypothermia, with obvious difference from the control group (P<0.05).
Moderate hypothermia can obviously reduce ICP and improve brain tissue oxygen metabolism to lower the morbidity and mortality rate of severe head injury.
观察亚低温（33 - 35摄氏度）治疗重度颅脑损伤时颅内压（ICP）和脑组织氧分压（PO₂）的变化及其意义。
18例重度颅脑损伤患者采用亚低温治疗，将探头置于大脑皮层，在持续监测下测量其ICP和PO₂。另外14例接受相同治疗但未进行亚低温治疗的类似患者作为对照组。
亚低温治疗组在低温24小时后ICP逐渐下降，PO₂升高，与对照组差异明显（P<0.05）。
亚低温可明显降低ICP，改善脑组织氧代谢，降低重度颅脑损伤的发病率和死亡率。
Zotero 插件