Domasu S, Terada N, Sano H, Kodama M
First Department of Surgery, Shiga University of Medical Science, Otsu, Japan.
Nihon Geka Gakkai Zasshi. 1992 Jan;93(1):1-8.
Recent clinical and experimental studies have suggested that blood transfusion decreased immunological responsiveness. In order to investigate this mechanism, we performed following studies. In vivo experiments, we investigated the effect of blood transfusion on tumor growth and survival rate in mice, and added the comparative studies about the timing of blood transfusion and blood cell component transfusion. In vitro experiments, we studied on the responses of CTL and NK activity by the experimental model of postoperative blood transfusion. These experiments led to the following results: 1) Accelerated tumor growth and reduced survival rate were observed in allogeneic transfused mice. 2) These effects were seen independently of the timing of blood transfusion. 3) A transfusion of lymphocytes was capable of inducing this effect of blood transfusion. 4) Blood transfusion induced both suppression of anti-tumor CTL, TNP-CTL and NK activity. 5) The suppression of CTL was mediated by suppressor cells. From these results, it was suggested that allogenic blood transfusion induced immunosuppression in mice independently of its timing.
最近的临床和实验研究表明，输血会降低免疫反应性。为了研究这一机制，我们进行了以下研究。在体内实验中，我们研究了输血对小鼠肿瘤生长和存活率的影响，并增加了关于输血时间和血细胞成分输血的比较研究。在体外实验中，我们通过术后输血的实验模型研究了CTL和NK活性的反应。这些实验得出了以下结果：1）在接受异体输血的小鼠中观察到肿瘤生长加速和存活率降低。2）这些影响与输血时间无关。3）淋巴细胞输血能够诱导输血的这种效应。4）输血诱导了抗肿瘤CTL、TNP-CTL和NK活性的抑制。5）CTL的抑制是由抑制细胞介导的。从这些结果表明，异体输血在小鼠中诱导免疫抑制与其时间无关。
