厄他培南蛋白结合对细菌杀灭的影响。
Effect of ertapenem protein binding on killing of bacteria.
作者信息
Nix David E, Matthias Kathryn R, Ferguson Emily C
机构信息
Department of Pharmacy Practice and Science, College of Pharmacy, University of Arizona, 1703 E. Mabel St., P.O. Box 210-207, Tucson, AZ 85721-0207, USA.
出版信息
Antimicrob Agents Chemother. 2004 Sep;48(9):3419-24. doi: 10.1128/AAC.48.9.3419-3424.2004.
Abstract
The effect of protein binding on the antimicrobial activity of ertapenem was evaluated using the bacterial kill rate and concentration-response studies. Various proportions of human serum were utilized to determine the total and free-drug concentrations using a validated high-performance liquid chromatography assay. The MICs and kill curves were determined for test isolates of Enterobacter cloacae and Staphylococcus aureus at various percentages of human serum. The killing of bacteria was analyzed in relation to the free and total concentrations of ertapenem at various proportions of human serum. It was determined that unbound ertapenem was responsible for the antimicrobial activity against the test isolates.
摘要
使用细菌杀灭率和浓度-反应研究评估了蛋白结合对厄他培南抗菌活性的影响。利用不同比例的人血清，通过经过验证的高效液相色谱法测定总药物浓度和游离药物浓度。针对阴沟肠杆菌和金黄色葡萄球菌的测试分离株，在不同百分比的人血清中测定了最低抑菌浓度（MIC）和杀灭曲线。分析了在不同比例人血清中，细菌杀灭情况与厄他培南游离浓度和总浓度的关系。结果确定，未结合的厄他培南对测试分离株具有抗菌活性。
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