7T场强下的二维J-分辨螺旋光谱成像：在大鼠胶质瘤中移动脂质图谱绘制的应用

2D J-resolved spiral spectroscopic imaging at 7 T: application to mobile lipid mapping in a rat glioma.

作者信息

Hiba Bassem, Serduc Raphaël, Provent Peggy, Farion Régine, Rémy Chantal, Ziegler Anne

机构信息

Laboratoire Mixte INSERM-Université Joseph Fourier U594, Centre Hospitalier Universitaire, Grenoble, France.

出版信息

Magn Reson Med. 2004 Sep;52(3):658-62. doi: 10.1002/mrm.20166.

DOI:10.1002/mrm.20166

PMID:15334587

Abstract

Lactate (Lac) and mobile lipids (Lip), which are present in rat gliomas, are difficult to map because their 1H resonances overlap in the 1.3 ppm region. 2D J-resolved spectroscopy enables proper separation of the two resonance lines. To obtain high-spatial-resolution mapping of Lac and Lip resonances within a reasonable experiment time, we coupled 2D J-resolved spectroscopy with a fast spectroscopic imaging (SI) method, based on an out-and-in spiral k-space description. The method was applied to a rat glioma at 7 T, and Lac and Lip maps were reconstructed. The duration of SI (2D spatial, 2D spectral) was 64 min for a theoretical in-plane resolution of 1 x 1 mm, and a slice thickness of 2 mm (voxel size 8.2 microl, taking into account the point-spread function (PSF)).

摘要

乳酸（Lac）和流动脂质（Lip）存在于大鼠胶质瘤中，由于它们的1H共振在1.3 ppm区域重叠，因此难以绘制图谱。二维J分辨光谱能够使两条共振线得到适当分离。为了在合理的实验时间内获得Lac和Lip共振的高空间分辨率图谱，我们基于进出螺旋k空间描述，将二维J分辨光谱与快速光谱成像（SI）方法相结合。该方法应用于7 T的大鼠胶质瘤，重建了Lac和Lip图谱。对于理论平面分辨率为1×1 mm、切片厚度为2 mm（考虑点扩散函数（PSF）时体素大小为8.2微升）的情况，SI（二维空间、二维光谱）的持续时间为64分钟。