灵长类疟疾发病过程中及氯喹治疗后宿主调节性糖酵解酶的变化。

Alterations in host regulatory glycolytic enzymes during pathogenesis of primate malaria and following chloroquine therapy.

作者信息

Sahni S K, Saxena N, Puri S K, Dutta G P, Pandey V C

机构信息

Division of Biochemistry, Central Drug Research Institute, Lucknow, India.

出版信息

Int J Parasitol. 1992 Apr;22(2):247-9. doi: 10.1016/0020-7519(92)90110-7.

DOI:10.1016/0020-7519(92)90110-7

PMID:1534081

Abstract

Hexokinase, phosphofructokinase and pyruvate kinase, the regulatory enzymes of the glycolytic sequence, showed progressive increases in their activities with the rise of parasitaemia in Plasmodium knowlesi-infected rhesus monkey serum and red blood cells. Chloroquine therapy cleared the parasitaemia in 72 h and brought the elevated levels of these enzymes back to almost normal in about 30 days.

摘要

己糖激酶、磷酸果糖激酶和丙酮酸激酶是糖酵解过程中的调节酶，在诺氏疟原虫感染的恒河猴血清和红细胞中，随着疟原虫血症的升高，它们的活性逐渐增加。氯喹治疗在72小时内清除了疟原虫血症，并在约30天内使这些酶的升高水平恢复到几乎正常。