新型恶唑啉基质金属蛋白酶抑制剂的合成与评估
Synthesis and evaluation of novel oxazoline MMP inhibitors.
作者信息
Cook Gregory R, Manivannan Ethirajan, Underdahl Thane, Lukacova Viera, Zhang Yufen, Balaz Stefan
机构信息
Center for Protease Research, Department of Chemistry, Biochemistry and Molecular Biology, North Dakota State University, Fargo, ND 58105, USA.
出版信息
Bioorg Med Chem Lett. 2004 Oct 4;14(19):4935-9. doi: 10.1016/j.bmcl.2004.07.023.
PMID:15341955
Abstract
MMP inhibitors with novel oxazoline zinc binding groups have been synthesized and evaluated. Selectivity for the inhibition of MMP-9 over MMP-1, MMP-2, and MMP-12 has been achieved in several cases.
摘要
已合成并评估了带有新型恶唑啉锌结合基团的基质金属蛋白酶（MMP）抑制剂。在一些情况下，已实现了对MMP-9的抑制相对于MMP-1、MMP-2和MMP-12的选择性。
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