辛伐他汀对心脏X综合征患者内皮功能的影响。

Effect of simvastatin on endothelial function in cardiac syndrome X patients.

作者信息

Fábián Emília, Varga Albert, Picano Eugenio, Vajo Zoltan, Rónaszéki Aladár, Csanády Miklós

机构信息

Department of Cardiology, Elizabeth Hospital, Budapest, Hungary.

出版信息

Am J Cardiol. 2004 Sep 1;94(5):652-5. doi: 10.1016/j.amjcard.2004.05.035.

DOI:10.1016/j.amjcard.2004.05.035

PMID:15342302

Abstract

Patients with cardiac syndrome X with mild hypercholesterolemia were randomized to placebo (n = 20) or simvastatin 20 mg/day (n = 20). In the simvastatin group, there was a significant (26%; p < 0.0001) decrease in total cholesterol, a 38% (p < 0.0001) decrease in low-density lipoprotein cholesterol levels, and 7% a (p < 0.0001) increase in high-density lipoprotein cholesterol levels, without significant changes in triglyceride levels. Brachial artery flow-mediated dilation increased significantly (52% relative increase, p < 0.0001), and the time to > 1-mm ST-segment depression during stress testing was longer by the end of the study (p < 0.0001).

摘要

患有轻度高胆固醇血症的心脏X综合征患者被随机分为安慰剂组（n = 20）或辛伐他汀20毫克/天组（n = 20）。在辛伐他汀组中，总胆固醇显著降低（26%；p < 0.0001），低密度脂蛋白胆固醇水平降低38%（p < 0.0001），高密度脂蛋白胆固醇水平升高7%（p < 0.0001），甘油三酯水平无显著变化。肱动脉血流介导的舒张显著增加（相对增加52%，p < 0.0001），并且在应激测试期间ST段压低> 1毫米的时间在研究结束时延长（p < 0.0001）。