Bengtson J P, Bengtsson A, Stengvist O
Department of Anaesthesia and Intensive Care, Sahlgren Hospital, University of Göteborg, Sweden.
Anaesth Intensive Care. 1992 May;20(2):191-5. doi: 10.1177/0310057X9202000213.
The uptake of enflurane and of isoflurane were studied in forty patients during anaesthesia with nitrous oxide using either spontaneous or controlled ventilation. A Douglas bag method was used in combination with low fresh gas flows to a circle system and constant end-tidal anaesthetic concentration. The mean enflurane uptake rates were between 24 and 14 ml.70kg-1.min-1 between 10 and 60 minutes. Corresponding isoflurane uptake rates were between 15 and 8 ml. 70 kg-1.min-1. The initial uptake rates were lower than expected from "the square root of time concept". During spontaneous ventilation, the anaesthetic uptake rates were similar or even higher than corresponding rates during controlled ventilation in spite of lower minute ventilation volumes.
在40例使用氧化亚氮麻醉的患者中，采用自主通气或控制通气，研究了安氟醚和异氟醚的摄取情况。采用道氏袋法，结合低新鲜气体流量至循环系统，并维持恒定的呼气末麻醉药浓度。在10至60分钟之间，安氟醚的平均摄取率为24至14ml·70kg⁻¹·min⁻¹。相应的异氟醚摄取率为15至8ml·70kg⁻¹·min⁻¹。初始摄取率低于根据“时间平方根概念”预期的值。在自主通气期间，尽管分钟通气量较低，但麻醉药摄取率与控制通气期间的相应摄取率相似甚至更高。
