心脏瓣膜发育：内皮细胞信号传导与分化
Heart valve development: endothelial cell signaling and differentiation.
作者信息
Armstrong Ehrin J, Bischoff Joyce
机构信息
Vascular Biology Program and Department of Surgery, Children's Hospital Boston, Harvard Medical School, MA 02115, USA.
出版信息
Circ Res. 2004 Sep 3;95(5):459-70. doi: 10.1161/01.RES.0000141146.95728.da.
Abstract
During the past decade, single gene disruption in mice and large-scale mutagenesis screens in zebrafish have elucidated many fundamental genetic pathways that govern early heart patterning and differentiation. Specifically, a number of genes have been revealed serendipitously to play important and selective roles in cardiac valve development. These initially surprising results have now converged on a finite number of signaling pathways that regulate endothelial proliferation and differentiation in developing and postnatal heart valves. This review highlights the roles of the most well-established ligands and signaling pathways, including VEGF, NFATc1, Notch, Wnt/beta-catenin, BMP/TGF-beta, ErbB, and NF1/Ras. Based on the interactions among and relative timing of these pathways, a signaling network model for heart valve development is proposed.
摘要
在过去十年中，小鼠单基因敲除和斑马鱼大规模诱变筛选阐明了许多控制早期心脏模式形成和分化的基本遗传途径。具体而言，一些基因在心脏瓣膜发育中意外地发挥了重要且具有选择性的作用。这些最初令人惊讶的结果现在汇聚到了有限数量的信号通路，这些信号通路调节发育中和出生后心脏瓣膜中的内皮细胞增殖和分化。本综述重点介绍了最成熟的配体和信号通路的作用，包括血管内皮生长因子（VEGF）、活化T细胞核因子c1（NFATc1）、Notch、Wnt/β-连环蛋白、骨形态发生蛋白（BMP）/转化生长因子-β（TGF-β）、表皮生长因子受体（ErbB）和神经纤维瘤病1型（NF1）/Ras。基于这些通路之间的相互作用和相对时间，提出了一个心脏瓣膜发育的信号网络模型。
相似文献
1
Heart valve development: endothelial cell signaling and differentiation.心脏瓣膜发育：内皮细胞信号传导与分化
Circ Res. 2004 Sep 3;95(5):459-70. doi: 10.1161/01.RES.0000141146.95728.da.
2
Directed Differentiation of Human Induced Pluripotent Stem Cells to Heart Valve Cells.人诱导多能干细胞向心脏瓣膜细胞的定向分化。
Circulation. 2024 Apr 30;149(18):1435-1456. doi: 10.1161/CIRCULATIONAHA.123.065143. Epub 2024 Feb 15.
3
Rosiglitazone antagonizes vascular endothelial growth factor signaling and nuclear factor of activated T cells activation in cardiac valve endothelium.罗格列酮拮抗心脏瓣膜内皮细胞中血管内皮生长因子信号传导及活化T细胞核因子的激活。
Endothelium. 2006 May-Jun;13(3):181-90. doi: 10.1080/10623320600760308.
4
Co-ordinating Notch, BMP, and TGF-β signaling during heart valve development.协调心脏瓣膜发育过程中 Notch、BMP 和 TGF-β 信号通路。
Cell Mol Life Sci. 2013 Aug;70(16):2899-917. doi: 10.1007/s00018-012-1197-9. Epub 2012 Nov 16.
5
Regulation of endothelial cell differentiation and arterial specification by VEGF and Notch signaling.血管内皮生长因子（VEGF）和Notch信号对内皮细胞分化及动脉特化的调控
Anat Sci Int. 2009 Sep;84(3):95-101. doi: 10.1007/s12565-009-0026-1. Epub 2009 Mar 4.
6
Genetic interaction between pku300 and fbn2b controls endocardial cell proliferation and valve development in zebrafish.pku300 和 fbn2b 之间的遗传相互作用控制斑马鱼心内膜细胞的增殖和瓣膜发育。
J Cell Sci. 2013 Mar 15;126(Pt 6):1381-91. doi: 10.1242/jcs.116996. Epub 2013 Feb 15.
7
Wnt signaling in heart valve development and osteogenic gene induction.Wnt 信号在心脏瓣膜发育和成骨基因诱导中的作用。
Dev Biol. 2010 Feb 15;338(2):127-35. doi: 10.1016/j.ydbio.2009.11.030. Epub 2009 Dec 1.
8
Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-beta2.人肺动脉瓣祖细胞在血管内皮生长因子-A和转化生长因子-β2的作用下表现出内皮/间充质可塑性。
Circ Res. 2006 Oct 13;99(8):861-9. doi: 10.1161/01.RES.0000245188.41002.2c. Epub 2006 Sep 14.
9
Vascular endothelial growth factor receptor signaling is required for cardiac valve formation in zebrafish.血管内皮生长因子受体信号传导是斑马鱼心脏瓣膜形成所必需的。
Dev Dyn. 2006 Jan;235(1):29-37. doi: 10.1002/dvdy.20559.
10
VEGF signaling has distinct spatiotemporal roles during heart valve development.VEGF 信号在心脏瓣膜发育过程中具有独特的时空作用。
Dev Biol. 2010 Nov 15;347(2):325-36. doi: 10.1016/j.ydbio.2010.08.030. Epub 2010 Sep 15.
引用本文的文献
1
Unveiling the intricacies of cardiac valve pathophysiology.揭示心脏瓣膜病理生理学的复杂性。
Front Cardiovasc Med. 2025 Jul 24;12:1570271. doi: 10.3389/fcvm.2025.1570271. eCollection 2025.
2
Valve cells are crucial for efficient cardiac performance in Drosophila.瓣膜细胞对果蝇心脏的高效运作至关重要。
PLoS Genet. 2025 Mar 20;21(3):e1011613. doi: 10.1371/journal.pgen.1011613. eCollection 2025 Mar.
3
Endothelial-to-mesenchymal transition in the tumor microenvironment: Roles of transforming growth factor-β and matrix metalloproteins.肿瘤微环境中的内皮-间充质转化：转化生长因子-β和基质金属蛋白酶的作用
Heliyon. 2024 Nov 5;10(21):e40118. doi: 10.1016/j.heliyon.2024.e40118. eCollection 2024 Nov 15.
4
Manic Fringe promotes endothelial-to-mesenchymal transition mediated by the Notch signalling pathway during heart valve development.“狂躁边缘”蛋白在心脏瓣膜发育过程中促进由Notch信号通路介导的内皮-间充质转化。
J Mol Med (Berl). 2025 Jan;103(1):51-71. doi: 10.1007/s00109-024-02492-y. Epub 2024 Nov 11.
5
Endothelial-to-Mesenchymal Transition in Cardiovascular Pathophysiology.心血管病理生理学中的内皮细胞向间充质转化。
Int J Mol Sci. 2024 Jun 4;25(11):6180. doi: 10.3390/ijms25116180.
6
Zebrafish Congenital Heart Disease Models: Opportunities and Challenges.斑马鱼先天性心脏病模型：机遇与挑战。
Int J Mol Sci. 2024 May 29;25(11):5943. doi: 10.3390/ijms25115943.
7
Human Genetics of Hypoplastic Left Heart Syndrome.左心发育不全综合征的人类遗传学。
Adv Exp Med Biol. 2024;1441:937-945. doi: 10.1007/978-3-031-44087-8_60.
8
Molecular Pathways and Animal Models of Ebstein's Anomaly.Ebstein 畸形的分子途径和动物模型。
Adv Exp Med Biol. 2024;1441:915-928. doi: 10.1007/978-3-031-44087-8_58.
9
Molecular Pathways and Animal Models of Tricuspid Atresia and Univentricular Heart.三尖瓣闭锁和单心室的分子途径和动物模型。
Adv Exp Med Biol. 2024;1441:885-900. doi: 10.1007/978-3-031-44087-8_55.
10
Human Genetics of Semilunar Valve and Aortic Arch Anomalies.半月瓣和主动脉弓畸形的人类遗传学。
Adv Exp Med Biol. 2024;1441:761-775. doi: 10.1007/978-3-031-44087-8_45.
本文引用的文献
1
Three novel Notch genes in zebrafish: implications for vertebrate Notch gene evolution and function.斑马鱼中三个新的 Notch 基因：对脊椎动物 Notch 基因进化和功能的启示。
Dev Genes Evol. 1997 May;207(1):51-63. doi: 10.1007/s004270050091.
2
Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos.鸡和小鼠胚胎中心脏瓣膜小叶及支持装置的发育
Dev Dyn. 2004 Jun;230(2):239-50. doi: 10.1002/dvdy.20051.
3
Bone morphogenetic protein-2 can mediate myocardial regulation of atrioventricular cushion mesenchymal cell formation in mice.骨形态发生蛋白-2可介导小鼠心肌对房室垫间充质细胞形成的调节。
Dev Biol. 2004 May 15;269(2):505-18. doi: 10.1016/j.ydbio.2004.01.045.
4
Angiogenic modulators in valve development and disease: does valvular disease recapitulate developmental signaling pathways?
Curr Opin Cardiol. 2004 Mar;19(2):140-6. doi: 10.1097/00001573-200403000-00013.
5
DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice.在心脏瓣膜形成过程中，DSCR1基因的表达依赖于NFATc1，并且在16三体小鼠中与异常器官发育共定位。
Dev Biol. 2004 Feb 15;266(2):346-60. doi: 10.1016/j.ydbio.2003.10.036.
6
Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development.钙调神经磷酸酶信号传导与NFAT激活在心血管和骨骼肌发育中的作用
Dev Biol. 2004 Feb 1;266(1):1-16. doi: 10.1016/j.ydbio.2003.10.008.
7
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.Notch在心脏发育和致癌转化过程中促进上皮-间质转化。
Genes Dev. 2004 Jan 1;18(1):99-115. doi: 10.1101/gad.276304. Epub 2003 Dec 30.
8
Molecular markers of cardiac endocardial cushion development.心脏心内膜垫发育的分子标志物。
Dev Dyn. 2003 Dec;228(4):643-50. doi: 10.1002/dvdy.10418.
9
Control of endocardial cushion and cardiac valve maturation by BMP signaling pathways.骨形态发生蛋白信号通路对心内膜垫和心脏瓣膜成熟的调控
Mol Genet Metab. 2003 Sep-Oct;80(1-2):27-35. doi: 10.1016/j.ymgme.2003.07.004.
10
The Wnt/beta-catenin pathway regulates cardiac valve formation.Wnt/β-连环蛋白信号通路调控心脏瓣膜形成。
Nature. 2003 Oct 9;425(6958):633-7. doi: 10.1038/nature02028.
Zotero 插件