Neel Michael D, Heck Robert, Britton Lunetha, Daw Najat, Rao Bhaskar N
St. Jude Children's Research Hospital, Memphis, TN, USA.
Clin Orthop Relat Res. 2004 Sep(426):125-8. doi: 10.1097/01.blo.0000141386.97866.bb.
We conducted this study to determine whether the small-diameter, press-fit stem of a novel, noninvasive expandable endoprosthetic device implanted in the limbs of 6 pediatric patients with Stage IIB osteosarcoma affected the growth of the physis through which the stem was inserted. Local control of the tumor necessitated resection of the involved growth plate, and implantation of the device required penetration of the adjacent uninvolved bone, through the growth plate, by the stem of the device. We measured longitudinal growth and the rate of growth of the adjacent uninvolved bone in the salvaged limb and of the equivalent bone in the unoperated contralateral limb. In all cases but one (in which the patient's growth in the contralateral limb appeared complete), longitudinal growth continued in the limb into which the device was implanted: the adjacent uninvolved bone in the salvaged limb grew by an average of 2.4 cm, and the equivalent bone in the unoperated contralateral limb grew by an average of 2.3 cm. We conclude that implantation of a smooth, press-fit stem through the central portion of the uninvolved adjacent physis does not result in growth retardation or arrest.
我们开展这项研究,以确定植入6例IIB期骨肉瘤患儿肢体的一种新型非侵入性可扩张内置假体装置的小直径压配型柄,是否会影响该柄所穿过的生长板的生长。肿瘤的局部控制需要切除受累的生长板,而装置的植入需要装置的柄穿过生长板,穿透相邻未受累的骨骼。我们测量了保肢肢体中相邻未受累骨骼以及未手术对侧肢体中对应骨骼的纵向生长情况和生长速率。除1例(该例患者对侧肢体的生长似乎已完成)外,在所有病例中,植入装置的肢体的纵向生长均持续:保肢肢体中相邻未受累骨骼平均生长2.4厘米,未手术对侧肢体中对应骨骼平均生长2.3厘米。我们得出结论,通过未受累相邻生长板的中央部分植入光滑的压配型柄不会导致生长迟缓或生长停滞。