Nishimura Yoshihiro, Fukuchi Kazuki, Katafuchi Tetsuro, Sagou Masayoshi, Oka Hisashi, Ishida Yoshio, Murase Kenya
Department of Radiology, National Cardiovascular Center, Suita, Osaka, Japan.
J Nucl Med. 2004 Sep;45(9):1444-9.
Fusion of images of vascular anatomy and of myocardial perfusion images might be helpful for understanding the relationship between ischemia and the responsible vessels. The aim of this study was to develop a simple means of superimposing the images obtained from coronary angiography and gated myocardial perfusion SPECT.
Right and left oblique views from conventional coronary angiography and left ventriculography (LVG) were stored as 512 x 512 x 8-bit digital datasets and combined. We reconstructed images from routine gated myocardial perfusion imaging (MPI) by using (99m)Tc-tetrofosmin to match the oblique positions between the image from MPI and combined angiographic images. We then generated a 3-dimensional (3D) surface map by using the quantitative gated SPECT (QGS)/quantitative perfusion SPECT (QPS) program. Both the combined angiographic images and the 3D surface map were rescaled and unified by registering the internal landmarks between the 2 images. After subtraction of the LVG image, the coronary angiogram and the 3D surface map were fused into 1 image. All processes were performed with the QGS/QPS program and commercially available graphic software. We applied this method to datasets from a cardiac phantom and from several patients with coronary artery disease.
In the phantom study, our technique could obtain a 3D surface map in which the oblique angle was identified as that of radiography and could realize image registration and superimposition of radiography on scintigraphy. The preliminary results from the patients indicated that the markedly stenotic vessels showed good coincidence with the regional myocardial perfusion abnormalities on the unified images. In addition, these images could show the relationship between the coronary artery and regional wall motion in the gated mode.
We developed a simple method of superimposing the image of the coronary artery tree on images from gated MPI. The technique yielded useful information about myocardial perfusion and function as well as the supplying coronary artery.
血管解剖图像与心肌灌注图像的融合可能有助于理解缺血与责任血管之间的关系。本研究的目的是开发一种简单的方法，将冠状动脉造影和门控心肌灌注单光子发射计算机断层扫描（SPECT）获得的图像进行叠加。
将传统冠状动脉造影和左心室造影（LVG）的右前斜位和左前斜位视图存储为512×512×8位数字数据集并进行合并。我们使用锝-99m四膦酸盐从常规门控心肌灌注成像（MPI）重建图像，以匹配MPI图像与合并后的血管造影图像之间的斜位。然后，我们使用定量门控SPECT（QGS）/定量灌注SPECT（QPS）程序生成三维（3D）表面图。通过对两幅图像之间的内部标记进行配准，对合并后的血管造影图像和3D表面图进行重新缩放和统一。在减去LVG图像后，将冠状动脉造影和3D表面图融合为一幅图像。所有过程均使用QGS/QPS程序和市售图形软件进行。我们将该方法应用于心脏模型和几名冠心病患者的数据集。
在模型研究中，我们的技术可以获得一个3D表面图，其中斜角与放射摄影的斜角一致，并且可以实现放射摄影在闪烁显像上的图像配准和叠加。患者的初步结果表明，明显狭窄的血管与统一图像上的局部心肌灌注异常显示出良好的一致性。此外，这些图像可以在门控模式下显示冠状动脉与局部壁运动之间的关系。
我们开发了一种简单的方法，将冠状动脉树的图像叠加在门控MPI的图像上。该技术产生了关于心肌灌注和功能以及供应冠状动脉的有用信息。
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