Motz W
Herz- und Diabeteszentrum Mecklenburg-Vorpommern, Herz-Kreislaufforschung Universität Witten-Herdecke, Klinikum Karlsburg.
Internist (Berl). 2004 Oct;45(10):1108-16. doi: 10.1007/s00108-004-1273-9.
Left ventricular hypertrophy is the best known and most evident cardiac organ manifestation of arterial hypertension. However, only limited findings are available on function and structure of the right ventricle. The published studies show that the right ventricle is also affected in the course of hypertensive heart disease. Particularly hypertrophy of the right ventricular free wall, impaired right ventricular diastolic filling, elevated right ventricular filling pressure as well as impairment of right ventricular ejection fraction in the late phase of arterial hypertension were reported. Possible causes of these structural and functional changes of the right ventricle are (1) translation of the increased left ventricular filling pressure in the pulmonary circulation, (2) interaction of the right and left ventricle, and (3) systemic circulation of cytokines and growth hormones such as angiotensin II, aldosterone, and others.
左心室肥厚是动脉高血压最广为人知且最明显的心脏器官表现。然而,关于右心室功能和结构的研究结果有限。已发表的研究表明,在高血压性心脏病过程中右心室也会受到影响。尤其有报道称,在动脉高血压晚期,右心室游离壁肥厚、右心室舒张期充盈受损、右心室充盈压升高以及右心室射血分数受损。右心室这些结构和功能变化的可能原因包括:(1)肺循环中左心室充盈压升高的传导;(2)左右心室的相互作用;(3)细胞因子和生长激素(如血管紧张素II、醛固酮等)的全身循环。