Tamura Yasuhisa, Kataoka Yosky, Cui Yilong, Yamada Hisao
Department of Anatomy and Cell Science, Kansai Medical University, Moriguchi City, Osaka, Japan.
Neurosci Res. 2004 Sep;50(1):129-33. doi: 10.1016/j.neures.2004.06.011.
Cortical spreading depression (SD) is characterized by propagation of neuronal/glial membrane depolarization throughout the unilateral cerebral cortex and has been linked to several neurological disorders, including migraine aura and epilepsy. SD induction resulted in a dramatic increase in BrdU-incorporated cells in the ipsilateral cortical hemisphere that was dependent on the number of elicited SD. Immunohistochemical studies revealed that 53% of the BrdU-labeled cells in the SD-generated cortex were NG2 immunopositive and 25% were OX-42 immunopositive. The remaining 22% of BrdU-incorporated cells showed no immunoreactivity to GST-rr, GFAP, NeuN, NG2 or OX-42. These data indicate that functional excitation of the cerebral cortex induces proliferative response in cortical cells, which may subsequently differentiate into glial progenitor or microglia within 3 days after stimulation.
皮层扩散性抑制（SD）的特征是神经元/胶质细胞膜去极化在单侧大脑皮层中传播，并与多种神经系统疾病有关，包括偏头痛先兆和癫痫。诱导SD导致同侧皮层半球中掺入BrdU的细胞显著增加，这取决于诱发SD的次数。免疫组织化学研究显示，在由SD产生的皮层中，53%的BrdU标记细胞对NG2呈免疫阳性，25%对OX-42呈免疫阳性。其余22%掺入BrdU的细胞对GST-rr、GFAP、NeuN、NG2或OX-42无免疫反应性。这些数据表明，大脑皮层的功能性兴奋诱导皮层细胞的增殖反应，随后这些细胞可能在刺激后3天内分化为神经胶质祖细胞或小胶质细胞。
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