Kisa Cebrail, Aydemir Ciğdem, Devrim Başterzi Ayşe, Tüzer Verda, Göka Erol
Uzm., Ankara Numune Eğitim ve Araştirma Hastanesi 1. Psikiyatri Kl., Ankara.
Turk Psikiyatri Derg. 2004 Fall;15(3):175-81.
It is well known that bipolar disorder has familial transmission. Studies indicate that first-degree relatives of bipolar patients also have higher incidences of other mental disorders than the general population. The aim of this study is to determine the prevalence of mental disorders in the parents of bipolar patients.
Parents of 35 probands who were treated for their bipolar disorders and 35 age and gender matched healthy subjects' parents were assessed by means of the Structured Clinical Interview for DSM IV (SCID-I), and a questionnaire for the parents.
Past and current mental disorders were present in 27.1% of the parents of bipolar patients but in 14.2% of the parents of normal controls; the difference between the groups is statistically significant. The most prevalent mental disorder in both groups is major depressive disorder. The parents of bipolar patients were more likely to have a family history of mental disorder (44.2%) than the control group (12.8%). Parents who had a current or past mental disorder were more likely to have a family history of mental disease. Offspring of in-bred families had more bipolar siblings. Bipolar children of parents who had a family history of mental disorder tended to have an earlier age of onset.
The findings of this study indicate that there is an increased prevalence of bipolar disorders and other mental disorders in the parents of bipolar patients when compared to the parents of healthy controls.
众所周知，双相情感障碍具有家族遗传性。研究表明，双相情感障碍患者的一级亲属患其他精神障碍的几率也高于普通人群。本研究旨在确定双相情感障碍患者父母中精神障碍的患病率。
通过《精神疾病诊断与统计手册》第四版（DSM-IV）的结构化临床访谈（SCID-I）以及一份针对父母的问卷，对35名接受双相情感障碍治疗的先证者的父母和35名年龄及性别匹配的健康受试者的父母进行评估。
双相情感障碍患者父母中，过去或当前患有精神障碍的比例为27.1%，而正常对照组父母中的这一比例为14.2%；两组之间的差异具有统计学意义。两组中最常见的精神障碍均为重度抑郁症。双相情感障碍患者的父母比对照组（12.8%）更有可能有精神障碍家族史（44.2%）。有过当前或过去精神障碍的父母更有可能有精神疾病家族史。近亲家庭的后代有更多患双相情感障碍的兄弟姐妹。有精神障碍家族史的父母所生的双相情感障碍患儿发病年龄往往较早。
本研究结果表明，与健康对照者的父母相比，双相情感障碍患者的父母中双相情感障碍及其他精神障碍的患病率更高。
