[子宫内膜样腺癌中P53、P63和C-erbB-2的表达及其临床病理意义]

[Expression of P53, P63, and C-erbB-2 in endometrioid adenocarcinoma and their clinicopathological significance].

作者信息

Hu Wen-Fang, Liu Ming-Qiu, Zhao Qing

机构信息

Department of Obstetrics and Gynecology, Central Hospital of Huangshi City, Medical College, Wuhan University, Huangshi, Hubei, 435000, PR China.

出版信息

Ai Zheng. 2004 Sep;23(9):1021-5.

PMID:15363194

Abstract

BACKGROUND & OBJECTIVE: Tumor suppressor gene p53 and oncogene C-erbB-2 are confirmed to have close relation with endometrioid adenocarcinoma (EC), few documents have been reported about their correlation. Its structural homology to p53, p63 has been considered as a tumor suppressor gene acompany with p53 mutation, but its suppressive nature has not been confirmed yet; reports about p63 expression in EC are rare. This study was designed to investigate the roles of p53, p63, and C-erbB2 in tumorigenesis and development of EC, and their correlation with clinicopathological features of EC.

METHODS

Immunohistochemical technique was used to detect P53, P63, and C-erbB2 protein expression in 38 cases of EC, 23 cases of endometrial hyperplasia (EH), and 10 cases of benign proliferative endometrium (BPE).

RESULTS

(1) The positive rate of P53 in EC was 31.6%,significantly higher than those in EH and BPE (P < 0.05). P53 expression was associated with surgical pathologic stage, and depth of myometrial invasion in EC (P< 0.005), but was not associated with histological grade (P >0.05). (2) The positive rate of P63 in EC was 81.6%, significantly higher than those in EH and BPE (P < 0.005). P63 expression was not associated with histological grade, surgical pathologic stage, and depth of myometrial invasion in EC (P >0.05). (3) The positive rate of C-erbB-2 in EC was 23.2%, there was no significant difference compared with those in EH or BPE (P >0.05).C-erbB-2 expression was associated with surgical pathologic stage, and depth of myometrial invasion in EC (P< 0.001,P< 0.005),but was not associated with histological grade (P >0.05).(4) There was significantly positive correlation between P53 and P63 (r =0.443,P < 0.01)or C-erbB-2 (r =0.490,P < 0.005).

CONCLUSIONS

Both p53 and p63 are involved in carcinogenesis of EC; p63 may act as an oncogene in tumorigenesis of EC. The expression of P53 and C-erbB2 are related to the progression of malignant EC; P53 and C-erbB-2 co-expression may predict poor prognosis.

摘要

背景与目的

肿瘤抑制基因p53和癌基因C-erbB-2已被证实与子宫内膜样腺癌（EC）关系密切，但关于它们之间相关性的报道较少。p63与p53结构同源，在p53突变时被认为是一种肿瘤抑制基因，但其抑制特性尚未得到证实；关于p63在EC中表达的报道也很少。本研究旨在探讨p53、p63和C-erbB2在EC发生发展中的作用及其与EC临床病理特征的相关性。

方法

采用免疫组织化学技术检测38例EC、23例子宫内膜增生（EH）和10例良性增殖性子宫内膜（BPE）中P53、P63和C-erbB2蛋白的表达。

结果

（1）EC中P53阳性率为31.6%，显著高于EH和BPE（P<0.05）。P53表达与手术病理分期及EC中肌层浸润深度相关（P<0.005），但与组织学分级无关（P>0.05）。（2）EC中P63阳性率为81.6%，显著高于EH和BPE（P<0.005）。P63表达与EC的组织学分级、手术病理分期及肌层浸润深度无关（P>0.05）。（3）EC中C-erbB-2阳性率为23.2%，与EH或BPE相比无显著差异（P>0.05）。C-erbB-2表达与EC的手术病理分期及肌层浸润深度相关（P<0.001，P<0.005），但与组织学分级无关（P>0.05）。（4）P53与P63（r=0.443，P<0.01）或C-erbB-2（r=0.490，P<0.005）之间存在显著正相关。