Kan Xiu, Shen Dan-hua, Shi Bin, He Jing-sheng
Department of Pathology, People's Hospital, Peking University, Beijing 100044, China.
Zhonghua Bing Li Xue Za Zhi. 2004 Aug;33(4):312-5.
To study the morphologic classification of mammary ductal hyperplasia, and its criteria and the significance in distinguishing atypical hyperplasia from carcinoma-in-situ.
The clinicopathologic features of 300 cases of hyperplasia of breast were reviewed. Whole-organ H&E sections were also available in 86 cases of breast carcinoma. The occurrence of atypical hyperplasia in adjacent breast tissue was assessed.
Fibroadenomatoid changes were typically observed in the 21-30 age groups and atypical hyperplasia occurred more frequently in 40-60 age groups. Amongst the hyperplastic cases, cystic diseases of the breast were noted in only 6%. In contrast, fibroadenomatoid changes were more common (25.4%). Atypical ductal hyperplasia occurred in adjacent breast tissue of 65.1% of the carcinoma cases. The incidence was higher (74.9%) if the main lesion was ductal carcinoma-in-situ.
There is a close association between atypical hyperplasia and breast carcinoma. It is prudent to distinguish between usual and atypical hyperplasia. Morphologic differentiation between atypical ductal hyperplasia and ductal carcinoma-in-situ may sometimes be difficult.
研究乳腺导管增生的形态学分类、其标准以及鉴别非典型增生与原位癌的意义。
回顾300例乳腺增生的临床病理特征。86例乳腺癌病例还提供了全器官苏木精-伊红染色切片。评估相邻乳腺组织中非典型增生的发生情况。
纤维腺瘤样改变多见于21 - 30岁年龄组，非典型增生在40 - 60岁年龄组更为常见。在增生病例中，仅6%为乳腺囊性疾病。相比之下，纤维腺瘤样改变更为常见（25.4%）。65.1%的癌病例相邻乳腺组织出现非典型导管增生。如果主要病变为导管原位癌，发生率更高（74.9%）。
非典型增生与乳腺癌之间存在密切关联。区分普通增生和非典型增生是谨慎的做法。非典型导管增生与导管原位癌之间的形态学鉴别有时可能困难。
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