Radouco-Thomas Monelly, Bolduc Michel, Brisson Anick, Brassard Pierre, Fortier Lucie, Thivierge Jacques
The Mental Deficiency Program, CHRG, Laval University, Quebec City, Canada G1J 2G3.
Prog Neuropsychopharmacol Biol Psychiatry. 2004 Aug;28(5):879-83. doi: 10.1016/j.pnpbp.2004.05.029.
To explore the status of the psychotropic medication in persons with mental retardation 6 years after their deinstitutionalization.
The authors compared the profiles of psychotropic medication of 60 persons with mental retardation deinstitutionalized (D-sample) from our local mental hospital 6 years ago, to their actual pharmacological profile. Later, we compared our results to the ones of persons with mental retardation on an in-patient (In-sample) unit where existed a concerted team effort to lower the medication when deemed appropriate.
Six years post-deinstitutionalization, the authors observed that the same percentage of patients remained on antipsychotic and benzodiazepine medication in our D-sample, and a threefold increase of those using antidepressive medication. However, we observe a general decrease of all types of psychotropic medication in the In-sample with complete withdrawal in a substantial number of patients.
The authors take these pilot data to mean that a concerted team effort at lowering medication in persons with mental retardation makes a significant difference. The possibility of other factors (age, sex, severity of mental retardation, psychiatric diagnosis) explaining the difference in the results is discussed.
探讨智力障碍者机构化照护解除6年后精神药物的使用情况。
作者将6年前从当地精神病院解除机构化照护的60名智力障碍者(D样本)的精神药物使用情况与其实际用药情况进行比较。之后,将我们的结果与住院部(住院样本)智力障碍者的结果进行比较,住院部有一个协同团队,在认为适当时会努力减少用药。
机构化照护解除6年后,作者观察到在我们的D样本中,服用抗精神病药物和苯二氮䓬类药物的患者比例相同,而使用抗抑郁药物的患者增加了两倍。然而,我们观察到住院样本中所有类型的精神药物普遍减少,相当多的患者完全停药。
作者认为这些初步数据意味着在智力障碍者中通过团队协同努力减少用药会产生显著差异。文中还讨论了其他因素(年龄、性别、智力障碍严重程度、精神疾病诊断)解释结果差异的可能性。