大鼠对甲基苯丙胺辨别刺激效应的行为敏化
Behavioral sensitization to the discriminative stimulus effects of methamphetamine in rats.
作者信息
Suzuki Tsutomu, Fukuoka Yoshie, Mori Tomohisa, Miyatake Mayumi, Narita Minoru
机构信息
Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo 142-8501, Japan.
出版信息
Eur J Pharmacol. 2004 Sep 13;498(1-3):157-61. doi: 10.1016/j.ejphar.2004.07.064.
Sensitization to the discriminative stimulus effects of psychostimulants is not fully understood. Therefore, the present study was designed to investigate the development of sensitization to the discriminative stimulus of methamphetamine in rats. A dose-response curve for methamphetamine and a generalization test for cocaine were recorded in rats trained to discriminate between 1.0 mg/kg methamphetamine and saline. A significant leftward shift of the dose-response curve for methamphetamine and of the dose-generalization curve for cocaine was observed following repeated administration of methamphetamine (2.0 mg/kg) instead of saline. These findings suggest that repeated administration of methamphetamine can produce behavioral sensitization to the discriminative stimulus effects of methamphetamine in rats.
对精神兴奋剂辨别刺激效应的敏化作用尚未完全被理解。因此，本研究旨在调查大鼠对甲基苯丙胺辨别刺激的敏化作用发展情况。在训练大鼠辨别1.0毫克/千克甲基苯丙胺和生理盐水的实验中，记录了甲基苯丙胺的剂量反应曲线和可卡因的泛化测试。在重复给予甲基苯丙胺（2.0毫克/千克）而非生理盐水后，观察到甲基苯丙胺的剂量反应曲线和可卡因的剂量泛化曲线显著向左移动。这些发现表明，重复给予甲基苯丙胺可使大鼠对甲基苯丙胺的辨别刺激效应产生行为敏化。
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