Rowe J, Poolman J T, Macaubas C, Sly P D, Loh R, Holt P G
The University of Western Australia, West Perth, WA 6872, Australia.
Vaccine. 2004 Sep 28;22(29-30):3986-92. doi: 10.1016/j.vaccine.2004.03.052.
The known protective effects of passively acquired maternal antibody on the resistance of newborns to infections have prompted widespread interest in maternal vaccination. However, a range of animal model and human studies indicate potential inhibitory effects of maternal antibody on vaccine-specific humoral responses in infants. In the present study we have examined the relationship between maternally acquired TT-specific IgG present before DTaP vaccination and subsequent TT-specific T-cell memory responses at 12 and 18 months, in a cohort of 118 infants. We demonstrate a strong positive association between TT-specific cellular immunity as evidenced by increased IL-4, IL-5 and IL-13 responses, and maternal TT-specific IgG.
被动获得的母源抗体对新生儿抗感染的已知保护作用引发了人们对母体疫苗接种的广泛关注。然而，一系列动物模型和人体研究表明，母源抗体可能会抑制婴儿疫苗特异性体液反应。在本研究中，我们在118名婴儿队列中，检测了在白百破疫苗（DTaP）接种前存在的母源获得性破伤风特异性IgG与12个月和18个月时随后的破伤风特异性T细胞记忆反应之间的关系。我们证明，IL-4、IL-5和IL-13反应增加所证明的破伤风特异性细胞免疫与母源破伤风特异性IgG之间存在强正相关。
