肺移植术后支气管动脉血运重建可恢复支气管周围组织的氧合。
Bronchial artery revascularization restores peribronchial tissue oxygenation after lung transplantation.
作者信息
Kamler Markus, Nowak Kai, Bock Matthias, Herold Ulf, Motsch Johann, Hagl Siegfried, Gebhard Martha Maria, Jakob Heinz
机构信息
Department of Thoracic and Cardiovascular Surgery, University of Essen, Essen, Germany.
出版信息
J Heart Lung Transplant. 2004 Jun;23(6):763-6. doi: 10.1016/j.healun.2003.07.016.
With the interruption of the bronchial arteries after lung transplantation, nutritive support is dependent on collateral flow by the pulmonary arteries with desaturated venous blood. Consequently, oxygen deficiency of the peribronchial and dependent lung tissue may occur. Using a canine model for left lung transplantation, we investigated hypoxic peribronchial tissue after conventional lung transplantation and demonstrated restitution of tissue oxygenation after transplantation with bronchial artery revascularization (BAR) (BAR group: Po2 120.4 +/- 28.7 mm Hg; control group Po2 6.8 +/- 2.8; p < 0.001). BAR in lung transplantation protects peribronchial tissue of the transplanted graft from hypoxia in the early phase after reperfusion.
肺移植后支气管动脉中断，营养支持依赖于肺动脉携带的未饱和静脉血的侧支循环。因此，支气管周围和下垂肺组织可能会出现缺氧。我们使用犬左肺移植模型，研究了传统肺移植后支气管周围组织的缺氧情况，并证明了支气管动脉再血管化（BAR）移植后组织氧合的恢复（BAR组：Po2为120.4±28.7毫米汞柱；对照组Po2为6.8±2.8；p<0.001）。肺移植中的BAR可在再灌注后的早期保护移植肺的支气管周围组织免受缺氧影响。
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