Verhave J C, Hillege H L, Burgerhof J G M, Janssen W M T, Gansevoort R T, Navis G J, de Zeeuw D, de Jong P E
Division of Nephrology, Department of Medicine, University Medical Center Groningen, Groningen University Institute of Drug Exploration (GUIDE), Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
J Intern Med. 2004 Oct;256(4):324-30. doi: 10.1111/j.1365-2796.2004.01390.x.
To examine the relationship between sodium intake and urinary albumin excretion, being an established risk marker for later cardiovascular morbidity and mortality.
Cross-sectional cohort study using linear regression analysis. Setting. University hospital outpatient clinic.
A cohort drawn from the general population, consisting of 7850 subjects 28-75 years of age, all inhabitants of the city of Groningen, the Netherlands. The cohort is enriched for the presence of subjects with elevated urinary albumin concentration.
The results show a positive relationship between dietary sodium intake and urinary albumin excretion. The association was independent of other cardiovascular risk factors (such as sex, age, blood pressure, body mass index (BMI), waist-to-hip ratio, serum cholesterol, plasma glucose and smoking) and other food constituents (calcium, potassium and protein). The relationship between sodium intake and urinary albumin excretion was steeper in subjects with a higher BMI compared with a lower BMI.
Sodium intake is positively related to urinary albumin excretion. This relation is more pronounced in subjects with a higher BMI. These results suggest that high sodium intake may unfavourably influences cardiovascular prognosis especially in overweight and obese subjects.
研究钠摄入量与尿白蛋白排泄之间的关系，尿白蛋白排泄是心血管疾病发病和死亡的既定风险标志物。
采用线性回归分析的横断面队列研究。地点：大学医院门诊。
从一般人群中抽取的队列，由7850名28至75岁的受试者组成，均为荷兰格罗宁根市居民。该队列中尿白蛋白浓度升高的受试者有所增加。
结果显示饮食钠摄入量与尿白蛋白排泄之间存在正相关。这种关联独立于其他心血管危险因素（如性别、年龄、血压、体重指数（BMI）、腰臀比、血清胆固醇、血糖和吸烟）以及其他食物成分（钙、钾和蛋白质）。与BMI较低的受试者相比，BMI较高的受试者中钠摄入量与尿白蛋白排泄之间的关系更为明显。
钠摄入量与尿白蛋白排泄呈正相关。这种关系在BMI较高的受试者中更为明显。这些结果表明，高钠摄入可能对心血管预后产生不利影响，尤其是在超重和肥胖受试者中。
