First example of ring expansion of activated quinolines and isoquinolines: novel benzoazepines.
作者信息
Yadav J S, Reddy B V Subba, Gupta Manoj Kumar, Prabhakar A, Jagadeesh B
机构信息
Division of Organic Chemistry, Hyderabad-500 007, India.
出版信息
Chem Commun (Camb). 2004 Sep 21(18):2124-5. doi: 10.1039/b405100a. Epub 2004 Aug 2.
DOI:10.1039/b405100a
PMID:15368006
Abstract
Activated quinoline and isoquinoline undergo unexpected ring expansion by diazocarbonyl compounds via C-C insertion in the presence of 5 mol% of copper triflate to produce ethyl 1H-benzo[b]azepine-1-carboxylate and ethyl 3H-benzo[d]azepine-3-carboxylate, respectively, in excellent yields with a high degree of selectivity
摘要
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