表面结合的细胞外基质引发磷酸钙成核。

Nucleation of calcium phosphate by surface-bound extracellular matrix.

作者信息

Pham Minh Tan, Maitz Manfred Franz, Reuther Helfried, Muecklich Arndt, Prokert Friedrich, Steiner Gerald

机构信息

Forschungszentrum Rossendorf e.V., Institut für Ionenstrahlphysik und Materialforschung, Postfach 510119, 01314 Dresden, Deutschland.

出版信息

J Biomed Mater Res A. 2004 Oct 1;71(1):16-24. doi: 10.1002/jbm.a.30113.

DOI:10.1002/jbm.a.30113

PMID:15368251

Abstract

The native extracellular matrix (ECM) laid down on silicon and titanium surfaces by osteoblast-like SAOS-2 cells was exposed by selective removal of cells. This type of material surface ECM-Si, ECM-Ti was shown to promote the nucleation of calcium phosphate from a simulated body fluid (SBF). Microscopic and spectroscopic results revealed the effect was associated with a collagen fiber-free extracellular matrix.

摘要

通过选择性去除细胞，暴露出成骨样SAOS-2细胞在硅和钛表面沉积的天然细胞外基质（ECM）。这种材料表面的ECM-Si、ECM-Ti被证明能促进模拟体液（SBF）中磷酸钙的成核。显微镜和光谱结果表明，这种作用与无胶原纤维的细胞外基质有关。