紫外线B辐射会诱导大肠杆菌细胞中SoxS基因的表达吗？

Does UVB radiation induce SoxS gene expression in Escherichia coli cells?

作者信息

Gomes A A, Asad L M B O, Felzenszwalb I, Leitão A C, Silva A B, Guillobel H C R, Asad N R

机构信息

Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, 20551-030 Rio de Janeiro, RJ, Brazil.

出版信息

Radiat Environ Biophys. 2004 Sep;43(3):219-22. doi: 10.1007/s00411-004-0253-8. Epub 2004 Sep 14.

DOI:10.1007/s00411-004-0253-8

PMID:15372272

Abstract

The SoxRS regulon is induced when bacterial cells are exposed to redox-cycling agents such as menadione or paraquat. In this paper it is shown that a physical agent, such as ultraviolet radiation with a wavelength of 312 nm (UVB) can induce soxS gene expression. The results indicate that this induction involves the RpoS protein. Moreover, an unexpected increase of soxS gene expression independent of a functional soxR gene in UVB-irradiated cells has been verified. This increase could be explained by transcription of soxS gene in a rpoS-dependent pathway.

摘要

当细菌细胞暴露于氧化还原循环剂（如甲萘醌或百草枯）时，SoxRS调节子会被诱导。本文表明，一种物理因子，如波长为312nm的紫外线辐射（UVB）可诱导soxS基因表达。结果表明，这种诱导涉及RpoS蛋白。此外，已证实紫外线照射的细胞中soxS基因表达出现意外增加，且与功能性soxR基因无关。这种增加可以通过soxS基因在rpoS依赖性途径中的转录来解释。