ntrA在鼠伤寒沙门氏菌厌氧代谢中的作用。
The role of ntrA in the anaerobic metabolism of Salmonella typhimurium.
作者信息
Fasciano A, Hallenbeck P C
机构信息
Faculté de médecine, Université de Montréal, Département de microbiologie et immunologie, Québec, Canada.
出版信息
FEMS Microbiol Lett. 1992 Jan 1;69(2):101-4. doi: 10.1016/0378-1097(92)90611-q.
The possible involvement of NtrA in the expression of several anaerobically induced genes in Salmonella typhimurium was investigated. Unlike Escherichia coli, where hydrogenase 3 is ntrA dependent, the introduction of a mutation in ntrA had virtually no effect on the hydrogenase activity, thought to be hydrogenase 3, of S. typhimurium LT7. Fumarate reductase and alcohol dehydrogenase activities were found to be diminished in ntrA mutant strains, but this may very well be indirect since fdhF mutant strains showed the same effect. These results suggest that in S. typhimurium NtrA is highly specific for the anaerobic expression of fdhF.
研究了NtrA在鼠伤寒沙门氏菌中几种厌氧诱导基因表达中的可能作用。与大肠杆菌不同，在大肠杆菌中氢化酶3是ntrA依赖性的，而在鼠伤寒沙门氏菌LT7中，ntrA基因突变对被认为是氢化酶3的氢化酶活性几乎没有影响。富马酸还原酶和乙醇脱氢酶活性在ntrA突变菌株中降低，但这很可能是间接的，因为fdhF突变菌株也表现出相同的效应。这些结果表明，在鼠伤寒沙门氏菌中，NtrA对fdhF的厌氧表达具有高度特异性。
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