Wong Rene W G, Ooi Teik Chye, Benoit Brien, Zackon David, Jansen Gerard, Telner Adam
Division of Endocrinology and Metabolism, Ottawa Hospital, University of Ottawa, Canada.
Can J Neurol Sci. 2004 Aug;31(3):406-8. doi: 10.1017/s031716710000353x.
Lymphocytic hypophysitis is an autoimmune condition that commonly presents in women of childbearing age as hypopituitarism and a sellar mass.
A 66-year-old woman presented with anterior pituitary dysfunction. Computed tomography imaging revealed a small hypodensity that was not felt to be the cause of the pituitary dysfunction. Eight years later, her vision rapidly deteriorated and MRI showed a pituitary mass lesion causing optic chiasm compression. Histological examination of the partially resected gland revealed evidence of lymphocytic hypophysitis.
Our patient is an example of the variable presentation and course of lymphocytic hypophysitis. Such a long latent period between the initial presentation of adenohypophysial hypofunction and optic chiasm compression due to an enlarging pituitary mass has not been reported.
淋巴细胞性垂体炎是一种自身免疫性疾病，常见于育龄期女性，表现为垂体功能减退和鞍区肿块。
一名66岁女性出现垂体前叶功能障碍。计算机断层扫描成像显示一个小的低密度区，不认为是垂体功能障碍的原因。八年后，她的视力迅速恶化，磁共振成像显示垂体肿块病变压迫视交叉。对部分切除的腺体进行组织学检查发现淋巴细胞性垂体炎的证据。
我们的患者是淋巴细胞性垂体炎表现多样及病程多变的一个例子。腺垂体功能减退初次出现与垂体肿块增大导致视交叉受压之间如此长的潜伏期尚未见报道。
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