MPTP作为帕金森病的线粒体神经毒性模型。
MPTP as a mitochondrial neurotoxic model of Parkinson's disease.
作者信息
Przedborski Serge, Tieu Kim, Perier Celine, Vila Miquel
机构信息
Department of Neurology, Columbia University, New York, New York 10032, USA.
出版信息
J Bioenerg Biomembr. 2004 Aug;36(4):375-9. doi: 10.1023/B:JOBB.0000041771.66775.d5.
Abstract
1-Methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a potent neurotoxin extensively used to model Parkinson's disease (PD). A cascade of deleterous events, in which mitochondria play a pivotal role, drives MPTP neurotoxicity. How mitochondria are affected by MPTP and how their defect contributes to the demise of dopaminergic neurons in this model of PD are discussed in this review.
摘要
1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）是一种强效神经毒素，被广泛用于帕金森病（PD）模型的研究。一系列有害事件导致了MPTP的神经毒性，其中线粒体起着关键作用。本综述讨论了在该PD模型中，线粒体如何受到MPTP的影响，以及其缺陷如何导致多巴胺能神经元的死亡。
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