新皮质抑制系统的中间神经元。

Interneurons of the neocortical inhibitory system.

作者信息

Markram Henry, Toledo-Rodriguez Maria, Wang Yun, Gupta Anirudh, Silberberg Gilad, Wu Caizhi

机构信息

Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.

出版信息

Nat Rev Neurosci. 2004 Oct;5(10):793-807. doi: 10.1038/nrn1519.

DOI:10.1038/nrn1519

PMID:15378039

Abstract

Mammals adapt to a rapidly changing world because of the sophisticated cognitive functions that are supported by the neocortex. The neocortex, which forms almost 80% of the human brain, seems to have arisen from repeated duplication of a stereotypical microcircuit template with subtle specializations for different brain regions and species. The quest to unravel the blueprint of this template started more than a century ago and has revealed an immensely intricate design. The largest obstacle is the daunting variety of inhibitory interneurons that are found in the circuit. This review focuses on the organizing principles that govern the diversity of inhibitory interneurons and their circuits.

摘要

哺乳动物能够适应快速变化的世界，这得益于新皮层所支持的复杂认知功能。新皮层几乎构成了人类大脑的80%，它似乎源于一个刻板的微电路模板的反复复制，并针对不同的脑区和物种进行了细微的特化。一个多世纪前就开始了揭开这个模板蓝图的探索，并且已经揭示出了极其复杂的设计。最大的障碍是在该电路中发现的种类繁多、令人望而生畏的抑制性中间神经元。本综述聚焦于支配抑制性中间神经元及其电路多样性的组织原则。