异染色质：RNA指明方向。

Heterochromatin: RNA points the way.

作者信息

Birchler James A, Kavi Harsh H, Fernandez Harvey R

机构信息

Division of Biological Sciences, Tucker Hall, University of Missouri, Columbia, Missouri 65211, USA.

出版信息

Curr Biol. 2004 Sep 21;14(18):R759-61. doi: 10.1016/j.cub.2004.09.014.

DOI:10.1016/j.cub.2004.09.014

PMID:15380087

Abstract

Mutation of the multi-KH domain protein DPP1, which has single-stranded nucleic acid binding activity, suppresses heterochromatin-mediated silencing in Drosophila; it also disrupts the modification of histone H3 at lysine 9, and association of heterochromatin protein 1 on the heterochromatic regions, suggesting a role for DDP1 in heterochromatin formation.

摘要

具有单链核酸结合活性的多KH结构域蛋白DPP1发生突变，会抑制果蝇中异染色质介导的基因沉默；它还会破坏组蛋白H3在赖氨酸9处的修饰，以及异染色质蛋白1在异染色质区域的结合，这表明DDP1在异染色质形成中发挥作用。