下咽癌的 upfront 下颌下唾液腺转移术

Upfront submandibular salivary gland transfer in pharyngeal cancers.

作者信息

Pathak K A, Bhalavat R L, Mistry R C, Deshpande M S, Bhalla V, Desai S B, Malpani B L

机构信息

Department of Surgery, Tata Memorial Hospital, Dr. E. Borges Road, Parel, Mumbai 400 012, India.

出版信息

Oral Oncol. 2004 Oct;40(9):960-3. doi: 10.1016/j.oraloncology.2004.04.016.

DOI:10.1016/j.oraloncology.2004.04.016

PMID:15380176

Abstract

Head and neck irradiation results in salivary dysfunction and subsequent xerostomia. Twenty two patients with squamous cancer of oropharynx or hypopharynx underwent contralateral submandibular salivary gland transfer (SMSGT) to submental triangle to shield it from subsequent radiotherapy. Resting salivary outputs of transferred and untransferred gland (control) were measured before and after SMSGT and following radiotherapy, by cannulating individual submandibular duct. They were compared by paired samples t-test. Following radiation therapy transferred gland retained 73% and untransferred gland (control) retained 27% of baseline salivary output. This significant difference in post-radiation salivary outputs suggests preservation of function of transferred salivary gland.

摘要

头颈部放疗会导致唾液功能障碍及随后的口干症。22例口咽或下咽鳞状癌患者接受了对侧下颌下唾液腺转移术（SMSGT），即将下颌下唾液腺转移至颏下三角，以使其免受后续放疗的影响。在SMSGT前后以及放疗后，通过插入单个下颌下导管来测量转移唾液腺和未转移唾液腺（对照）的静息唾液分泌量。采用配对样本t检验对它们进行比较。放疗后，转移唾液腺保留了基线唾液分泌量的73%，未转移唾液腺（对照）保留了27%。放疗后唾液分泌量的这一显著差异表明转移唾液腺的功能得以保留。