Kiive Evelyn, Maaroos Jaak, Shlik Jakov, Tõru Innar, Harro Jaanus
Department of Psychology, Centre of Behavioural and Health Sciences, University of Tartu, Tiigi 78, Tartu, 50410, Estonia.
Prog Neuropsychopharmacol Biol Psychiatry. 2004 Sep;28(6):1007-13. doi: 10.1016/j.pnpbp.2004.05.035.
This study was designed to compare growth hormone, cortisol and prolactin responses to physical exercise in depressed patients and healthy comparison subjects. Patients fulfilled the DSM-IV diagnostic criteria for current major depressive disorder; subjective depressive symptoms were rated with Montgomery-Asberg Depression Rating Scale (MADRS) immediately before the experiment. Growth hormone, cortisol and prolactin were measured before and immediately after physiologically stressful bicycle cardiopulmonary exercise test. After exercise, there were three additional hormone measurements, with 30-min intervals. No significant difference was found in baseline growth hormone, cortisol or prolactin levels between patients and the control group. Plasma growth hormone and cortisol levels increased significantly during physical exercise in both patients and controls and returned to baseline in 90 min. There was no significant difference in growth hormone or cortisol responses to physical exercise between the two groups. However, prolactin levels increased only in the depressed patients group during the exercise. We hypothesize that acute exercise may have a stronger effect on serotonin (5-HT) release in depressed patients, which is reflected in increased plasma prolactin concentration.
本研究旨在比较抑郁症患者和健康对照者对体育锻炼的生长激素、皮质醇和催乳素反应。患者符合当前重度抑郁症的DSM-IV诊断标准；在实验前立即用蒙哥马利-阿斯伯格抑郁评定量表（MADRS）对主观抑郁症状进行评分。在生理应激性自行车心肺运动试验前后测量生长激素、皮质醇和催乳素。运动后，每隔30分钟额外进行三次激素测量。患者和对照组之间的基线生长激素、皮质醇或催乳素水平未发现显著差异。患者和对照组在体育锻炼期间血浆生长激素和皮质醇水平均显著升高，并在90分钟内恢复至基线水平。两组之间对体育锻炼的生长激素或皮质醇反应无显著差异。然而，仅抑郁症患者组在运动期间催乳素水平升高。我们假设急性运动可能对抑郁症患者的血清素（5-HT）释放有更强的影响，这反映在血浆催乳素浓度升高上。
