Fedotova Julia, Sapronov Nikolay
Department of Neuropharmacology, Research Institute for Experimental Medicine of the Russian Academy of Medical Sciences, 12 Academician Pavlov Street Petersburg 197376, Russia.
Prog Neuropsychopharmacol Biol Psychiatry. 2004 Sep;28(6):1023-7. doi: 10.1016/j.pnpbp.2004.05.037.
It is well-documented that dehydroepiandrosterone (DHEA) exhibits various behavioral effects in rodents, at least one of which is modulation of learning/memory processes in several test paradigms. However, little is known about the influence of DHEA on cognitive performance in the adult rodents. This work was designed to determine whether chronic DHEA administration during 10 days in the high (0.7 mg/kg, s.c.) or low (0.1 mg/kg, s.c.) doses has any effect on learning/memory abilities and behavior in the adult male rats (5- to 6-month old). Effect of DHEA was estimated in active and passive avoidance tasks, behavior was registered in the elevated "plus" maze and the "open field" test. DHEA in the high dose significantly (p<0.05) increased time spent and the number of enterings in the "open" arms of the elevated "plus" maze in intact male rats as compared with the control rats. DHEA in the low dose significantly (p<0.05) decreased horizontal and vertical locomotor activity and grooming behavior, whereas DHEA in the high dose did not significantly modify behavior in intact rats as compared with control group. Results of the ANOVA on passive avoidance performance revealed no statistically significant differences among the groups receiving DHEA in the high or low doses as compared to the control. However, DHEA in the low dose significantly (p<0.05) reduced the number of correct avoidance responses in intact rats as compared to the control rats, while in rats treated with the high dose DHEA, the active avoidance performance did not differ significantly from the control. Thus, chronic DHEA administration has a modulatory action on the learning and behavior of the adult male rats.
大量文献记载，脱氢表雄酮（DHEA）在啮齿动物中表现出多种行为效应，其中至少有一种效应是在几种测试范式中对学习/记忆过程的调节。然而，关于DHEA对成年啮齿动物认知能力的影响却知之甚少。本研究旨在确定在成年雄性大鼠（5至6个月大）中，连续10天皮下注射高剂量（0.7mg/kg）或低剂量（0.1mg/kg）的DHEA是否对其学习/记忆能力及行为有任何影响。在主动和被动回避任务中评估DHEA的作用，在高架“十字”迷宫和“旷场”试验中记录行为。与对照组相比，高剂量的DHEA显著（p<0.05）增加了完整雄性大鼠在高架“十字”迷宫“开放臂”中停留的时间和进入次数。低剂量的DHEA显著（p<0.05）降低了水平和垂直运动活动及梳理行为，而与对照组相比，高剂量的DHEA对完整大鼠的行为没有显著改变。对被动回避表现的方差分析结果显示，与对照组相比，接受高剂量或低剂量DHEA的组之间没有统计学上的显著差异。然而，与对照组相比，低剂量的DHEA显著（p<0.05）减少了完整大鼠正确回避反应的次数，而在接受高剂量DHEA治疗的大鼠中，主动回避表现与对照组没有显著差异。因此，长期给予DHEA对成年雄性大鼠的学习和行为具有调节作用。
