Rosty Christophe
Service de Pathologie, Institut Curie, 26, rue d'Ulm, 75248 Paris, FRANCE.
Bull Cancer. 2004 Jul-Aug;91(7-8):593-8.
The poor prognosis of pancreatic cancer has remained unchanged for many years, with a 5-year survival of less than 5 %. Current methods for diagnosing pancreatic cancer are inadequate at identifying small tumors that can be resected by surgery. Characterization of gene expression patterns in pancreatic cancer provided a list of genes that are specifically overexpressed in cancer cells. These genes are putative novel markers for the diagnosis and the prognosis of pancreatic cancer and for the development of targeted therapies. Gene expression analysis should lead to the discovery of molecular markers for early detection of pancreatic cancer that could benefit patients at high risk of developing pancreatic cancer.
胰腺癌的不良预后多年来一直未变,5年生存率低于5%。目前诊断胰腺癌的方法在识别可通过手术切除的小肿瘤方面存在不足。胰腺癌基因表达模式的特征分析提供了一份在癌细胞中特异性过度表达的基因清单。这些基因是胰腺癌诊断、预后及靶向治疗开发的潜在新型标志物。基因表达分析应能发现用于早期检测胰腺癌的分子标志物,这可能使罹患胰腺癌高风险的患者受益。