鸟分枝杆菌感染期间的肉芽肿坏死不需要肿瘤坏死因子。
Granuloma necrosis during Mycobacterium avium infection does not require tumor necrosis factor.
作者信息
Flórido Manuela, Appelberg Rui
机构信息
Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Proto, Porto, Portugal.
出版信息
Infect Immun. 2004 Oct;72(10):6139-41. doi: 10.1128/IAI.72.10.6139-6141.2004.
Abstract
The infection of tumor necrosis factor (TNF)-deficient mice with low doses of the virulent Mycobacterium avium strain 25291 led to the appearance of necrotic granulomas at 93 days of infection, i.e., sooner than necrotic granulomas appeared in C57BL/6 animals. Additionally, TNF-deficient mice exhibited higher mycobacterial loads in the infected organs, had extremely exacerbated gamma interferon responses as evaluated in the sera of infected animals, and showed reduced survival. Thus, TNF is not required for granuloma necrosis.
摘要
用低剂量的强毒鸟分枝杆菌菌株25291感染肿瘤坏死因子（TNF）缺陷小鼠，在感染93天时出现坏死性肉芽肿，即比C57BL/6动物出现坏死性肉芽肿的时间更早。此外，TNF缺陷小鼠在受感染器官中的分枝杆菌载量更高，在感染动物血清中评估的γ干扰素反应极度加剧，且生存率降低。因此，肉芽肿坏死不需要TNF。
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